Classification system for oral submucous fibrosis semantic scholar. It is characterised by inflammation and progressive fibrosis of the submucosal tissue. Osf can lead to squamous cell carcinoma, a risk that is further increased by concomitant tobacco consumption. Oral submucous fibrosis osf is a high risk precancerous condition characterized by.
Oral submucous fibrosis osf is a premalignant condition mainly associated with the practice of chewing betel quid containing areca nut, a habit common among south asian people. Oral submucous fibrosis osf is a medical condition that affects the mouth by causing inflammation of the mucous tissues and the formation of fibrous growths on the walls of the mouth. Treatment etiopathogenesis and management of oral submucous fibrosis seema basoya department of oral medicine and radiology, s. Oral submucous fibrosis osf is an extremely discomforting oral condition that is marked by the development of painful lesions inside the mouth that refuse to go away on their own. Mediators such as growth factors, hormones, cytokines, and. Over the last 40 years, many theories linking oral submucous fibrosis osmf to various risk factors have been proposed. It is suggested that submucous fibrosis should be regarded as a condition that causes predisposition to the development of oral cancer. A novel clinical protocol for therapeutic intervention in oral. Gupta s, reddy mvr, harinath bc, role of oxidative stress and antioxidants in aetiopathogenesis and management of oral submucous fibrosis, ind j clinbiochem, 19, 2004, 8. Oral submucous fibrosisa case report medcrave online. A case of oral submucous fibrosis occurring in a 11yearold bangladeshi girl is presented. The condition is remotely linked to oral cancers and is associated with areca nut or betel quid chewing, a habit. Spicy, pungent foods and irritants such as supari areca nut, paan betel leaves, tobacco through chewing or smokingthe common asian habits of chewing the aforementioned agentshave all been incriminated as causative agents. Oral submucous fibrosis is a chronic, complex, premalignant condition of the oral cavity, characterized by juxtaepithelial inflammatory reaction and progressive fibrosis of the submucosal tissues.
Combining instrumentation and sera in osf diagnosis. Oral submucous fibrosis is a chronic debilitating disease of the oral cavity characterized by inflammation and progressive fibrosis of the submucosal tissues lamina propria and deeper connective tissues. Oral submucous fibrosis osmf is a chronic disease of oral mucosa characterized by inflammation and progressive fibrosis followed by stiffening of an otherwise yielding mucosa resulting in difficulty in opening the. It is very common in southeast asia but has started. Unusual complication of intralesional corticosteroid in oral submucous fibrosis patient srikanth g 1, komal s 2, jyotsna r 1 and kalyana c. Novel mouthexercising device for oral submucous fibrosis pravinkumar g. Oraoral submucous fibrosis osmf is a chronic, insidious, disabling disease of oral mucosa, oropharynx, and rarely, the larynx affecting millions of people worldwide with a prevalence rate of 0.
Oral submucous fibrosis osmf is a potentially malignant disorder pmd and. Oral submucous fibrosis a disease with malignant potential. The rationale of using exfoliative cytology in our study lies in the epithelial physiology where continuous exfoliation of. Genetic expression signatures of oral submucous fibrosis and oral. Liver fibrosis results from chronic damage to the liver in conjunction with the accumulation of ecm proteins, which is a characteristic of most types of chronic liver diseases 1. It is a chronic insidious scarring disease of oral cavity, pharynx and. Nonhomologous end joining provides a mechanism for the repair of double strand. Characterization of muscle alteration in oral submucous fibrosis. Oral submucous fibrosis is a chronic debilitating disorder which is usually seen in adults with areca nut chewing habit. A retrospective study, int oral health, 7, 2015, 8285. It causes inflammation and progressive thickening of the lining of the mouth. Pdf oral submucous fibrosis osmf is a potentially malignant disorder pmd and.
Pubmed, embase, web of science, and the cochrane library were searched. The disease is rare in north america, and most cases seen in migrants from south east asia. Pathogenesis involved in the progression of osmf is mostly increased collagen synthesis andor reduced collagen degradation. Efficacy of hyaluronidase combined with corticosteroids in. Pdf classification system for oral submucous fibrosis. Oral submucous fibrosis causes, symptoms, treatment and. Oral submucous fibrosis osmf is a chronic inflammatory disease of the oral soft tissues with progressive juxtaepithelial fibrosis resulting in increasing difficulty in chewing, swallowing, speaking and mouth opening, often associated with burning sensation. Fibrosis results from the excessive activity of fibroblasts, in particular a differentiated form known as myofibroblast that is responsible for the excessive and persistent accumulation of scar.
Oral submucous fibrosis osf, first described in the early 1950s, is a potentially malignant disease predominantly seen in people of asian decent. Oral submucous fibrosis in a 11yearold bangladeshi girl. It results in difficulty to open the mouth and can be disabling to the patient. The aim of the study was to assess the progression of oral submucous fibrosis osf by investigating the correlation between clinical. Epithelial atrophy, juxtaepithelial inflammation and fibrosis of the lamina propria are common findings. Schwartz who studied a group of asianindian women living in.
Dr saikat saha mds, omfs, siliguri slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. It is associated with arecabetel nut chewing, areca nut being the main component of betel quid. Oral submucous fibrosis osmf is a high risk precancerous condition and its major etiological factor is chewing areca nut. The disease is rare in north america, and most cases seen in migrants from south east asia or india. Oral submucous fibrosis is a longlasting disease that affects the mouth. Although occasionally preceded andor associated with vesicle formation, is. Oral submucous fibrosis osf is a potentially malignant disorder of oral.
Novel mouthexercising device for oral submucous fibrosis. Author summary fibrosis is the final common pathway in virtually all forms of chronic organ failure, including lung, liver, and kidney, and is a leading cause of morbidity and mortality worldwide. Abstract oral submucous fibrosis osf is a chronic, insidious, and progressive oral mucosal. Oral submucous fibrosis osmf is a potentially malignant disorder. Oral submucous fibrosis in asian countries peng journal of oral. Information for patients charles clifford dental hospital.
Dr kalpajyoti bhattacharjee slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Symptoms include submucous fibrosis, ulceration, xerostomia, a burning sensation, and restricted mouth opening. Oral submucous fibrosis and its various treatment modalities inclusive of both nonsurgical and surgical management. It causes progressive immobilization of the jaw as the disease proceeds, resulting in total jaw paralysis over time. Oral submucous fibrosis a disease with malignant potential report.
It is a chronic progressive disorder and its clinical presentation depends on the stage of the disease at detection. Pdf oral submucous fibrosisa case report semantic scholar. Classification system for oral submucous fibrosis chandramani bhagvan more, swati gupta, jigar joshi, saurabh n varma abstract oral submucous fibrosis osmf is a potentially malignant disorder pmd and crippling condition of oral mucosa. Oral submucous fibrosis osf is characterized by abnormal collagen deposition. Oral submucous fibrosis results in marked rigidity.
It is caused as a result of addiction to harmful areca nut products with or without tobacco. All of these greatly interfere with patient quality of life. Oral submucous fibrosis osmf is a chronic, progressive disease that alters the fibroelasticity of the oral submucosa, prevalent in india and southeast asia but rare elsewhere, and characterized by burning and pain in the oral cavity, loss of gustatory sensation, the presence of blanched fibrous bands and stiffening of the oral mucosa and oro. Patil, mds2 1department of prosthodontics, government dental college and hospital, nagpur, india 2department of orthodontics and dentofacial orthopedics, sdks dental college and hospital, nagpur, india. O ral submucous fibrosis is a chronic, insidious disease affecting the oral cavity and sometimes pharynx. The available epidemiological data showed a clearcut geographical and ethnic predisposition, which suggested that certain customshabits prevalent among the population groups in southeast asia might be possible etiological factors. Oral submucous fibrosis a forerunner of tmj changes. Betel nut and pan are freely available in the united kingdom, and in a city such as leicester, one might expect to find 3000 cases of oral submucosal fibrosis. The main causes of liver fibrosis in industrialized countries include chronic hcv infection, alcohol abuse, and nonalcoholic steatohepatitis nash.
Oral submucous fibrosis is a chronic, progressive, irreversible and yet avoidable collagen metabolic disorder of the mouth caused by chewing areca nut in betel quid or its variants. Know all about the disease, including its possible causes, symptoms, diagnosis and treatment options. The awareness of such a condition among oral physicians can help in timely diagnosis and. Oral submucous fibrosis osmf is a condition that was first described in the 1950s. Pdf oral submucous fibrosis osf is a premalignant condition caused by betel chewing. It is a precancerous disorder and transforms into a malignant tumor in 1. A rapid upsurge in the popularity of commercial areca nut products, especially among the younger generation, is a cause of grave concern, as satisfactory management is still lacking. Pdf estimation of serum connective tissue growth factor. Oral submucous fibrosis osmf is a chronic disease affecting any part of the oral cavity. Oral submucous fibrosis osf is a premalignant condition caused by betel chewing.
Oral submucous fibrosis is a chronic disease of insidious onset featuring the deposition of fibrous tissue in the submucous layer of the palate, fauces, cheek, lips, pharynx and esophagus. As the disease progresses, the jaws become rigid to the point that the person is unable to open the mouth. Joshi subsequently coined the termed oral submucous fibrosis osf for the condition in 1953. Oral submucous fibrosis a study although many studies proved that main causative agent is areca nut. Because of insufficient research data, there is a need for highquality randomized, controlled. It is well recognised as potentially malignant disorder which is associated mainly with the use of arecanut in various forms. Oral submucous fibrosis osmf is a chronic, progressive, debilitating, scarring. Patil, mds2 1department of prosthodontics, government dental college and hospital, nagpur, india 2department of orthodontics and dentofacial orthopedics. Oral submucous fibrosis osmf is a common potentially malignant disease characterized by epithelial atrophy and progressive accumulation of collagen fibers in the underlying submucosal layer. Oral submucous fibrosis osf is the chronic debilitating and crippling condition of oral mucosa. Unusual complication of intralesional corticosteroid in. It resembles scleroderma but is localised to the mouth. Oral submucous fibrosis osmf, a precancerous condition of the oral cavity, has been studied by a number of workers in the field.
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